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A minimum lethal dose of nicotine in dogs is reported at 4 mg per pound body weight, but clinical signs have been seen at a dose of 0.4mg per pound body weight

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The detection of SBS4 (a hallmark of tobacco-induced mutagenesis) in the organoid model indicates that chronic WCSE exposure can elicit molecular alterations resembling those found in smoker-derived tumors, effectively bridging in vitro oxidative adaptation with in vivo mutational landscapes

Melin, MA, MD, FACP

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COPD (Chronic Obstructive Pulmonary Disease): A progressive disease that makes it hard to breathe, often manifested as chronic bronchitis or emphysema